David Segal, Ph.D.

David Segal

Position Title
Professor

Unit
Biochemistry
Molecular Medicine

Bio

Role: Molecular Genomics and Epigenomics Analyses and Translational Interventions.

Dr. Segal holds joint appointments in the UC Davis School of Medicine, the Genome Center, and the MIND Institute. His research focuses on the study of gene and epigenetic information in health and disease. He has 19 years of experience engineering gene and epigenetic editing systems as molecular tools and therapeutics, with over 90 publications in this field. His laboratory has had funding from the NIH-NIGMS, NINDS, NHGRI, NCI, DOD and foundations including the Foundation for Angelman Syndrome Therapeutics, W.M. Keck Foundation, and the Bill and Melinda Gates Foundation, to use targeted nucleases and transcription factors to study and regulate genetic information. He is the Director of the Genetic Analysis component of the NIH-funded Somatic Cell Genome Editing Consortium Large Animal Testing Center. He is a Co-Investigator on U54CA233306 “University of California Minority Patient-Derived Xenograft (PDX) Development and Trial Center (UCaMP) to Reduce Cancer Health Disparities” He has co-mentored students with Co-PI Janine LaSalle, and these collaborations have led to several co-authored publications of human epigenetics.